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Of the drugs in this class, bupropion (Wellbutrin, Wellbutrin SR), mirtazapine (Remeron), nefazodone (Serzone), venlafaxine (Effexor, Effexor XR), and maprotiline (Ludiomil) are typically the most used in clinical practice.

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Duloxetine (Cymbalta) is the newest drug in this class being approved in 2004.

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This group of drugs, including Effexor XR treat depression and anxiety by acting on two brain chemicals called serotonin and norepinephrine.

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